Effects of oestradiol treatment on hot flushes in men undergoing androgen deprivation therapy for prostate cancer: a randomised placebo-controlled trial

Abstract

Objective: Most men undergoing androgen deprivation therapy (ADT) for pro state cancer experience hot flushes. Current treatments have low or limited evidence of efficacy. It i s likely that oestradiol depletion is the mediator of these hot flushes, and transdermal oestradiol might be an effecti ve treatment. Design: This is a 6-month randomised, placebo-controlled trial with th e hypothesis that oestradiol would reduce hot flush frequency and intensity and improve quality of life (QoL). Methods: Seventy-eight participants receiving ADT were randomised to 0.9 mg of 0.1% oestradiol gel per day or matched placebo. Hot flush frequency and severity were assessed by 7-day diary at baseline, month..